ABSTRACT
Figure 6.2 Gap junctions in the immune defense against tumors. (a) Cx43 is localized at cell-cell contacts between human mature DCs (mDCs). Immature and mature DCs were costained for Cx43 (green) and CD11c (red). High-power confocal magnification shows Cx43 at cell-cell contacts, colocalizing with CD11c (arrowheads). Scale bar = 20 mm. (b) Cx43 accumulates at the immunological synapse in an antigen (Ag)-specific way. Representative images of Cx43 and LFA-1 distribution after incubation of OVA-DCs (DC + Ag) or LPSDCs (DC (−) Ag) with OT-II T cells are shown. Scale bar = 5 mm.
