ABSTRACT

I. INTRODUCTION The field of maintenance has changed considerably, perhaps more than any other business discipline over the past 50 years, and the pharmaceutical industry is also responding to these changes by addressing maintenance and reliability issues better to produce life-saving products, on time, on cost, on quality, and safely with respect for personnel, property, and the environment. Many leading pharmaceutical companies and biotechnology firms have been investing in developing asset care programs and manufacturing excellence strategies over the past 20 years to implement strategic plans for equipment maintenance and reliability.