ABSTRACT
Published and unpublished qualitative, semi-quantitative, and quantitative data on cutaneous absorption of this essential trace element brought in contact with the skin in its metallic form and its organic and inorganic species are reviewed. The different approaches that have been used to investigate copper diffusion and analysis of results are dicussed, as well as problems associated with their interpretation. Diffusion constants Kp registered range from 107 to 103 cm/h. Recognized as a critical endogenous anti-inflammatory agent in the normal organism, inflammatory conditions induce an increased demand in the organism for copper; such demand could potentially be satisfied by dermal exposure. Role and importance of copper’s anti-inflammatory activity and the possibility of transdermal dosing is viewed in light of the metal’s skin diffusivity data now available.
