ABSTRACT
This chapter reviews the imaging findings of common drug-induced histopathological injuries including diffuse alveolar damage, non-specific interstitial pneumonia, bronchiolitis obliterans organizing pneumonia (BOOP), eosinophilic pneumonia, diffuse pulmonary haemorrhage (DPH) and pulmonary oedema. It focuses on pulmonary manifestations of drug-induced disease; at least passing mention should be made of extrapulmonary findings related to drug exposures that may be encountered. Diffuse alveolar damage is a common manifestation of drug-induced lung injury that can be divided into an acute exudative phase and a late reparative or proliferative phase. BOOP is characterized by the formation of granulation tissue plugs in the respiratory bronchioles, alveolar ducts and adjacent alveolar spaces. Diffuse pulmonary haemorrhage can be a manifestation of drug-induced lung injury with potentially significant morbidity and mortality; however, DPH is an uncommon complication of drug therapy. Bleomycin is an antineoplastic antibiotic that results in lung injury in up to 5 per cent of treated patients.
