ABSTRACT
With the increasing threats of new infections and antibiotic resistance of microbes, nding new drugs has never been so pressing. While organic synthesis continues to improve the effectiveness of available drugs, nding new backbones of chemical structures is crucial in the long-term development of effective drugs. Traditionally, soil micro organ isms from terrestrial habitats have been explored for chemical diversity, and many compounds have been isolated and used in the market.1 However, repeated isolation of phylogenetically related organisms may have resulted in compounds with similar physical, chemical, biochemical, or pharmacological properties. For the past couple of
CONTENTS
13.1 Introduction .......................................................................................................................... 379 13.2 Where the Sea Meets the Land .............................................................................................380 13.3 Fungi at Ocean−Land Interface ............................................................................................ 381
13.3.1 Secondary Metabolites of Fungi from Marine and Marine-Related Habitats ......... 382 13.4 Labyrinthulomycetes in Mangroves ..................................................................................... 383
13.4.1 Omega-3 Polyunsaturated Fatty Acids .....................................................................384 13.4.2 Squalene .................................................................................................................... 385 13.4.3 Carotenoids ............................................................................................................... 385
13.5 Areas for Further Research .................................................................................................. 386 13.6 Conclusions ........................................................................................................................... 386 Acknowledgments .......................................................................................................................... 387 References ...................................................................................................................................... 387
decades, new chemical structures have been isolated from marine organisms, implicating a niche for drug discovery research.
