ABSTRACT

Baldomero M. Olivera, Helena Safavi-Hemami, Martin P. Horvath, and Russell W. Teichert Department of Biology, University of Utah, Salt Lake City, Utah

CONTENTS

16.1 Background ...........................................................................................................................464 16.1.1 From the Beach: A History of Humans and Cone Snails .........................................464 16.1.2 Insights into Cone Snail Biology Based on Phylogenetic Data ................................466

16.2 Cone Snail Venoms: Biomedical Applications .....................................................................469 16.2.1 History of Conus Venom Research ..........................................................................469 16.2.2 Diagnostic Applications ............................................................................................ 471 16.2.3 Therapeutic Applications of Conus Peptides ........................................................... 471

16.3 Molecular Mechanisms of Conopeptide Diversity and Targeting Selectivity ...................... 473 16.3.1 Overview of Conopeptide Diversity ......................................................................... 473