ABSTRACT
Introduction 1552 Role of inflammatory and autoimmune disorders in the 1552
pathogenesis of lymphoproliferative disorders MALT-type marginal zone lymphoma in extranodal tissues: 1552
Helicobacter pylori and MALT lymphoma Immunoproliferative small intestinal disease 1554 Skin marginal zone lymphoma and Borrelia 1554 Ocular adnexa lymphoma 1554 MALT-type marginal zone lymphoma in the salivary 1554
gland and Sjögren syndrome Splenic marginal zone lymphoma 1554 Chronic lymphocytic leukemia and autoimmune disorders 1555 Celiac disease and intestinal T cell lymphoma 1555 Pyothorax-associated lymphoma 1555
Hodgkin lymphoma and Epstein-Barr virus 1555 Endemic Burkitt lymphoma, Epstein-Barr virus, 1555
and dentinogenesis Less frequent tumors 1556 Chemokines 1556 Introduction 1556 Role of chemokines in specific lymphoma types 1556 Non-tumoral cell populations 1559 Introduction 1559 Hodgkin lymphoma 1559 Angioimmunoblastic T cell lymphoma 1560 Follicular lymphoma 1561 Key points 1561 References 1562
The growth of lymphoma cells may depend not only on the accumulation of genetic alterations but also on signals derived from the milieu that drive cell proliferation or inhibit apoptosis. The relevance of the microenvironment to lymphoma pathogenesis has been highlighted by the observations linking specific microbial and viral pathogens to specific types of lymphoproliferative syndromes. However, it has also become apparent that lymphoma development is dependent on a particular stromal microenvironment that conditions the nature of the developed neoplasms.
