ABSTRACT
The non-Hodgkin lymphomas (NHLs) comprise about 10 percent of all childhood cancers and are typically intermediate compared to ‘high-grade’ tumors.1 By immunophenotype, the pediatric NHLs are evenly divided between B and T cell neoplasms.1 The four major pathologic subtypes of pediatric NHL include Burkitt lymphoma, diffuse large B cell lymphoma (DLBCL), anaplastic large cell lymphoma (ALCL), and lymphoblastic lymphoma. Diffuse large B cell lymphoma is the least common NHL in children and makes up approximately 10-20 percent of cases.2 However, it is the most common histologic subtype of NHL seen in teenagers.
