ABSTRACT
Introduction 1455 Mature B cell neoplasms 1456 Follicular lymphoma 1456 Extranodal marginal zone B cell lymphoma of 1456
mucosal-associated lymphoid tissue (MALT) and nodal marginal zone B cell lymphomas
Mature T cell neoplasms 1457
Hepatosplenic T cell lymphoma 1457 Subcutaneous panniculitis-like T cell lymphoma 1457 Extranodal natural killer/T cell lymphoma, nasal type 1458 Mycosis fungoides 1458 T cell large granular lymphocytic leukemia 1459 Key points 1459 References 1459
One of the largest series of uncommon histologic subtypes of non-Hodgkin lymphoma (NHL) occurring in children was reported by Ribeiro et al.1 approximately 15 years ago. Patients were classified according to the National Cancer Institute (NCI) Working Formulaton.2 An uncommon histologic subtype was identified in 36 of 1336 cases (2.7 percent) of newly diagnosed NHL in children treated at either St. Jude Children’s Research Hospital or at a participating Pediatric Oncology Group institution.1 Among these 36 cases, 17 were identified as having follicular histology and 19 were classified as having diffuse histology of low or intermediate grade. Among the 17 follicular cases, six were described as mixed small and large cell, nine as large cell, and two as small noncleaved cell. Among the 19 cases with diffuse histology, 18 were described as mixed small cell and large cell and one as small cell lymphocytic.
