ABSTRACT

Maxwell and Delaney (1990) describe a study in which the effects of three possible treatments for hypertension were investigated. The details of the treatments are as follows:

All 12 combinations of the three treatments were included in a 3 × 2 × 2 design. Seventy-two subjects suffering from hypertension were recruited, and six were allocated randomly to each combination of treatments. Blood pressure measurements were made on each subject leading to the data shown in Table 4.1. Questions of interest concern differences in mean blood pressure for the different levels of the three treatments and the effects of interactions between the treatments on blood pressure.