ABSTRACT
One of the basic natural antioxidants, α-tocopherol (the most biologically active form of vitamin E) plays the significant role in regulation of peroxidation processes [1-3]. Besides the familiar role as lipid-soluble chain-terminating inhibitor of lipid peroxidation the structural role of αtocopherol (TP) in membranes was also proposed [2]. TP may enhance curvature stress or counteract similar stresses induced by other lipids such as lysoforms of phospholipids [2]. In this connection the interrelation between the TP content and the relative content of lysoforms of phospholipids would be paid a special attention in this research. The biological consequences of the radiation action are due to the level of the antioxidant activity (AOA) of the tissue lipids, the activities of the antioxidant defense enzymes and the lipid peroxidation (LPO) intensity in organs and tissues of animals and also their ability to repair and normalization after the radiation injury [4-7]. Besides, it’s very important to analyze the interrelation between α-tocopherol content and the lipid composition of the murine tissues in order to prognosticate the mechanism of the inhibitory effectiveness of antioxidants in the presence of phospholipids and sterols, because in model systems they affect the activity of nature and synthetic antioxidants [8-11]. The AOA level itself is connected with the antioxidants content in the tissue lipids [4], thus, the consequence of the acute irradiation may be resulted from the TP content and its inhibitory effectiveness in the various tissues of mice.
