ABSTRACT
Key Points ...................................................................................................................................... 281 Introduction .................................................................................................................................... 282 Fructose and Hypertension ............................................................................................................ 282 Animal Studies ............................................................................................................................... 282
Role of Uric Acid ...................................................................................................................... 282 Direct Vascular Effects ..............................................................................................................284 SNS Activation and Leptin ........................................................................................................284 Relationship with Sodium Intake ..............................................................................................284
Human Studies ...............................................................................................................................284 Does Fructose Increase Serum Uric Acid?................................................................................284 Does Fructose Raise BP in Humans? ........................................................................................285 Is Fructose Intake Associated with Hypertension in Humans? .................................................285 Does Reducing Fructose Intake Lower BP? .............................................................................288
Summary: Role of Fructose in Hypertension .................................................................................288 Fructose and Kidney Disease .........................................................................................................288 Experimental Studies .....................................................................................................................288
