ABSTRACT
The development of new nanomaterials has a signicant inuence on bioanalytical chemistry. The unique properties of ordered graphene (G) have stimulated intense research interests in multidisciplinary science because of its unique band structures, massless fermions, and ultrahigh carrier mobility. The G-based analytical tools can enhance the analytical performance with excellent sensitivity and selectivity for the detection of a variety of molecules. In this chapter, we present the information on G and its applications in laser desorption/ionization mass spectrometry (LDI-MS) for analysis of various chemical and biological molecules. We also provide many examples from the last 5 years regarding the bioanalytical applications of G-graphene oxide (GO) and carbonbased LDI-MS approaches for sensitive and selective analysis of various molecules. Furthermore, we also demonstrate the utility of G and carbon materials as molecular spacers and as afnity probes to maintain the activity of the enzyme and to concentrate the target species prior to their identication by LDI-MS. Finally, the future perspective of G-based LDI-MS approaches for biological applications is discussed.
