A large proportion of patients with chronic hepatitis C virus infection complain of a variety of non-specific symptoms that are not directly attributable to their liver disease and that are not related to pre-existing psychiatric disease. These symptoms include:
• profound fatigue with non-refreshing sleep;
• generalized aches and pains in all limbs; • intermittent or persistent arthralgia
without evident synovitis or joint inflammation;
• difficulty in concentrating; and • complaints of short-term memory loss.