ABSTRACT
Antiphospholipid syndrome (APS) is a systemic autoimmune disorder of vascular thrombosis and/or pregnancy complications. This disease is defined by the presence of both clinical and laboratory criteria.1 The clinical manifestations of obstetric APS include recurrent early miscarriage, fetal loss, early and/or severe pre-eclampsia, and intrauterine growth restriction (IUGR). Thrombotic APS may include arterial or venous thrombotic events, such as stroke or deep vein thrombosis, or thrombotic microangiopathy. Laboratory criteria include one or more of the following autoantibodies at medium to high titers on more than one occasion at least 12 weeks apart: lupus anticoagulant (LAC), anticardiolipin antibodies (aCL), and/or anti-β2-glycoprotein-I antibodies (aβ2GPI).
