ABSTRACT
Most work on recurrent miscarriage has concentrated on the causes, prognosis, treatment, and subsequent live birth rate. However, this group of patients is also at a higher risk for obstetric complications such as bleeding, fetal anomalies, pre-eclampsia, intrauterine growth restriction (IUGR), preterm labor, and perinatal mortality. Consequently, prenatal care should be modified to seek these complications. It is unclear whether these late obstetric complications are associated with specific conditions such as antiphospholipid syndrome or hereditary thrombophilias or are associated with recurrent pregnancy loss per se. Various interventions have also been reported to affect the incidence of later obstetric complications. These interventions include paternal leucocyte immunization and intravenous immunoglobulin for unexplained recurrent pregnancy loss, anticoagulants and aspirin or intravenous immunoglobulin for antiphospholipid syndrome, and anticoagulants for hereditary thrombophilias. This chapter assesses some of the obstetric complications associated with different forms of recurrent pregnancy loss and the treatment modalities that have been used.
