chapter  11
12 Pages

Acute Systemic Toxicity Testing and Device Safety Evaluation

In the pharmaceutical industry, acute toxicity testing has uses other than for product safety determinations. First, as in other industries, acute toxicity determinations are part of industrial hygiene or occupational health environmental impact assessments. These requirements demand testing not only for nished products but frequently of intermediates as well (Rowan, 1981; Gad et al., 1984). These issues and requirements, however, are discussed in Chapter 2, and are not directly addressed here.