ABSTRACT
Plasmablastic differentiation can be found in a wide range of large B-cell lymphomas, including plasmablastic lymphoma, plasmablastic lymphoma with plasmacytic differentiation, primary effusion lymphoma. Plasmablastic lymphoma may occur as a posttransplant lymphoproliferative disorder. Typical plasmablastic lymphoma shows diffuse and monotonous infiltrate of large cells with either plasmablastic or immunoblastic morphology. Cases of plasmablastic lymphoma with plasmacytic differentiation show variable numbers of cells with plasmacytic differentiation and monoclonal light-chain expression. Large B-cell lymphoma expressing the anaplastic lymphoma kinase is a rare variant of diffuse large B-cell lymphoma with immunoblastic or plasmablastic morphology and cytoplasmic expression of anaplastic lymphoma kinase. Reactive component is less prominent in monomorphic variant, which is characterized by sheets of large B-cells. Lymphomatoid granulomatosis is an Epstein–Barr virus -associated B-cell lymphoproliferative process characterized by an angiocentric/angiodestructive growth pattern with a polymorphous lymphoid infiltrate composed of a variable number of large B cells and reactive small T lymphocytes.
