ABSTRACT
Hodgkin lymphoma (HL) is divided into classical HL and nodular lymphocyte predominant HL. Classical HL is a B-cell neoplasm characterized by the presence of Reed–Sternberg cells and an accompanying polymorphic inflammatory infiltrate with eosinophils, histiocytes, small lymphocytes, and plasma cells caused by cytokine production by the neoplastic cells. The incidence of HL has a bimodal pattern, with the highest incidence seen in young adults and elderly patients. HL can occur in the setting of rheumatoid arthritis after methotrexate treatment, but the majority of lymphomas in those patients are of B lineage. High content of histiocytes is significantly correlated with poor prognosis in HL patients. Nodular Sclerosis HL is the most common subtype of classical HL. Mixed cellularity HL is a subtype of classical HL with increased numbers of large neoplastic cells and numerous polymorphic inflammatory cells without broad bands of fibrosis, thickened capsule, or the nodular architecture.
