ABSTRACT
Physical inactivity is a major contributor to the development of lifestyle-related diseases, including cardiovascular diseases (Lee et al. 2013; Oppewal et al. 2013), certain tumors, type 2 diabetes (Kasuga et al. 2013), osteoporosis (Janssen 2012), and even neurodegenerative diseases (Radak et al. 2010; Janssen 2012). This could be partly because the development of the genome at the genesis of humans was associated with a physically active lifestyle. It has been suggested that Stone Age man used 4000 kcal for physical activity on a daily basis (Radak et al. 2013c). Adaptive changes on the DNA sequence are very slow. Therefore, it is not surprising that physical inactivity is a risk factor for a wide range of diseases.
