ABSTRACT
Magnetic nanoparticles (MNPs) have many applications in different areas of biology and medicine. MNPs are used for hyperthermia, magnetic resonance imaging, immunoassay, purification of biologic fluids, cell and molecular separation, tissue engineering [1-6]. The design of magnetically targeted nanosystems (MNSs) for a smart delivery of drugs to target cells is a promising direction of nanobiotechnology. They traditionally consist on one or more magnetic cores and biological or synthetic molecules, which serve as a basis for polyfunctional coatings on MNPs surface. The coatings of MNSs should meet several important requirements [7]. They should be biocompatible, protect magnetic cores from influence of biological liquids, prevent MNSs agglomeration in dispersion, provide MNSs localization in biological targets and homogenity of MNSs sizes. The coatings must be fixed on MNPs surface and contain therapeutic products (drugs or genes) and biovectors for recognition by biological systems. The model which is often used when MNSs are developed is presented in Fig. 1.
