ABSTRACT
Vaginal agenesis is a rare condition diagnosed most commonly at the time of puberty or early adolescence in the course of an evaluation for amenorrhea or pelvic pain. The earliest references to vaginal agenesis and a proposed therapy can be found in Hippocrates’ work, On the Nature of Women. He alluded to a “membranous obstruction” of the vagina that was amenable to the persistent insertion of a pessary to lengthen the vagina. The first descriptions recorded in the medical literature were by Engle in an autopsy report and the surgical correction by Dupuytren in 1817.
