chapter  8
30 Pages

Cell and tissue engineering

The rst attempt to develop an organ culture method was attempted in 1897, which employed an adult rabbit liver, kidney, and thyroid on small plasma clots and observed

that these bioengineered organs retained their normal histological features for 3 days. Later in 1919 it was reported that the culture tube can be lled with oxygen to prevent necrosis of the cells. The various organ culture methods are briey described.