ABSTRACT
Melatonin (Mel) is an important signal molecule that is known as the basic secretory product of the pineal gland. It is in a component of unicellular organisms, plants, and fungi and is additionally found in other organisms, such as animals and humans (Odaci and Kaplan, 2009; Aygun et al., 2012). Nonsteroidal anti-inammatory drugs (NSAIDs) are widely used for the purpose of antiinammation, antipyretic, and analgesia (Aygun et al., 2012). Although they are common prescription, toxic side effects of NSAIDs have been widely investigated (Canan et al., 2008). This chapter summarizes the physiology of Mel and discusses the potential therapeutic uses of Mel on the possible toxic effects of NSAIDs.
