ABSTRACT
Production of reactive oxygen species (ROS) is one of the early effects of ionizing radiation, which induces the cellular antioxidant defense enzymes such as superoxide dismutase and glutathione peroxidase [1]. ROS and free radicals react with cellular macromolecules (i.e., nucleic acids, lipids, and carbohydrates) and cause damage. Oxidative damage to living cells can be estimated with measurable major biomarkers of lipid peroxidation such as penthane, isoprostane, and aldehytic products measurable in tissue and body uids; DNA-hydroxylation products and microscopic indices of damage such as chromosomal aberrations and micronuclei and protein hydroxylation products such as oxidized amino acids can also be detected [2].
