6 Pages

Purify A: Screen l2yrl


Initially, the strategy of screening natural product extracts involved evaluation of a certain number of extracts every month for a period of several years while the assay remained in the screening program (Figure 3A). The most potent active extracts identified during this time would be sequentially added to a purification list for structure identification. The main drawback with this approach was that extracts containing the most active compounds might not be screened until two years after the first extracts were evaluated for activity in the assay.