ABSTRACT
One of the most important problems in genome mapping is that of ordering a set of genes, which are known to belong to the same chromosome. This is a very difficult task considering the fact that there are over 100,000 genes to order on twenty-three pairs of chromosomes in humans. The construction of the human genetic map was boosted by DNA sequencing (restriction fragment-length polymorphism (RFLP)) and new techniques in molecular genetics. For a good introduction, the reader is referred to the recent papers of Goradia and Lange (1990) and Karlin and Macken (1991). See also Boehnke et al. (1989), Buetow et al. (1991) and Donis-Keller et al. (1987).
