ABSTRACT
In this chapter we discuss some features of a prognostic factor analysis based on the Cox proportional hazards (PH) model. We present an analysis of the CNS lymphoma data introduced in Example 2 in Chapter 1.1. The primary endpoint of interest here is survival time (in years) from first blood brain barrier disruption (BBBD) to death (B3TODEATH). Some questions of interest are:
1. Is there a difference in survival between the two groups (prior radiation, no radiation prior to first BBBD)?
