ABSTRACT
The interaction of dipyridamole with reversed micelles formed by CI'AC in CDC13 was studied by 1 H NMR and spin-probe ESR (57). The binding parameters were estimated from selective T1 data. The results have shown that dipyridamole incorporates into the reversed micelles of CI'AC in CDCl3 in the polar region influencing packing and dynamics of surfactant molecules, principally, their headgroups. In reversed micelles, the affinity of dipyridamole is lower, and the microenvironment of dipyridamole substituents is more polar as compared with those in aqueous CI'AC micelles ( 18). These data highlight the variations in behavior of dipyridamole between different models, which may reflect the actual versatlltty of its interactions with tissue components in vivo.
