ABSTRACT
Innovations in analytical technology have often played an important role in the
progress of natural product chemistry. The characterisation of metabolites in complex
mixtures requires sophisticated hyphenated techniques, which should provide good
sensitivity and selectivity as well as structural information on the constituents of inter-
est. With the introduction of high throughput screening programmes, there is an urgent
need for even more efficient and sensitive methodologies, which yield adequate on-line
information for metabolite structure determination.
