ABSTRACT
Historically, tablets were primarily made by wet granulation. The attributes of flowability, compressibility, and wettability were considered best achievable by means of such a process. That certain products (effervescent tablets, aspirin) would have to be processed dry, led the way to what is known as direct compression. It is illogical, to first add water to a mass of powder, and then to remove it, and if it is possible to simply mix powders and compress them, then the process would become less laborintensive and more economical. Some aspects might be lost (e.g., wettability), it might become more difficult to meet content uniformity standards, but the aspects of economics has made direct compression attractive.
