ABSTRACT
The effectiveness of piperazine in Enterobius vermicularis was first reported by Mouriquand et al. (1). A series of open studies conducted later confirmed those earlier findings (8-11).
rates between 70 and 95%. The dose used was 1.5 g of piperazine given in the evening and in the morning. Using a dose of 36 mg/kg of piperazine, Brown and Sterman (14) reported cure rates of 92% after 5 days of therapy; 87% after 4 days of therapy; 93% after 3 days of therapy; and 85% after 2 days of therapy. In another study (12), the same author treated 99 patients with ascariasis with a single dose of 50-75 mg/kg piperazine, and reported a cure rate of 74% after 1-day treatment, and 94% after 2-day treatment.
