ABSTRACT
MW: 249; pKa: 7.3. The drug is practically insoluble in water. It should be stored in airtight containers and be protected from light.
Pharmacology and mechanism of action
Pyrimethamine is a diaminopyrimidine which is structurally related to trimethoprim. It is effective against erythrocytic stage of Plasmodium (P) falciparum and less so against P. vivax, P. ovale and P. malariae. Pyrimethamine also inhibits the sporogony in the mosquito, resulting in a decrease of transmission of the infection within the community (1).
