ABSTRACT
Tinidazole is given orally, parenterally and as suppository. Its oral bioavailability is close to 100% (3). The suppositories have a bioavailability of 60-70% (4). Peak plasma concentrations of around 40 µg/ml are achieved within 2 hours of a 2 g dose. Tinidazole is widely distributed and concentrations similar to those in plasma have been achieved in bile, breast milk, cerebrospinal fluid and saliva. It crosses the placenta readily. It has an apparent volume of distribution of around 0.6 l/kg, and is only slightly bound to plasma proteins (<20%) (5).
