chapter  7
32 Pages

Anti-Infective Coatings Reduce Device-Related Infections

Indw ellin g m edical devices have become a part of modem medical practices by providing doctors and surgeons with less invasive thera­ pies to treat diseases, administer nutrients, obtain blood samples, deliver medicines to specific locations in the body, and so forth. How­ ever, there are some problems associated with indwelling medical devices, among which infection is by far one of the major clinical com­ plications. In spite of non-septic conditions during the surgical process and systemic administration of antibiotics, the incidence of infections caused by bacteria is still high [1,2]. Even routine replacement (every three days) of central vascular catheters, which is one of the devices with high infection rates, does not solve the problem of catheterrelated infections [3]. Prevention of device-related infections remains a major dilemma in the delivery of quality medical care, and the prob­ lem causes high rates of mortality and morbidity and significant increases in health care costs [4-8]. In addition, extensive use of antibiotics to treat device-associated infections has contributed to the acceleration of the appearance of antibiotic-resistant bacteria by spreading through contaminated hospital environments to patients

BIOLOGY ON THE SURFACES OF INDWELLING DEVICES

Biofilm Formations The Nature of Bacteria

indwelling medical devices and various tissues [21] and dental decay [22], are known to be involved by surface adhesion of bacteria.