chapter  10
21 Pages

Merging of Biomedical and Textile Technologiesin Order to Create Infection-Resistant Prosthetic Vascular Grafts

Infectio n of prosthetic arterial vascular grafts persists as one of the most serious complications in modem vascular surgery. Although a sterile environment is maintained throughout the surgical procedure, the most common route for bacterial inoculation of a prosthetic graft is hypothesized to occur at the time of implantation. Perioperative antibiotics, while essential for wound prophylaxis, fail to prevent graft infection upon inoculation potentially due to insufficient penetration of antibiotics into graft interspaces as well as through the biofilm of adherent organisms. Thus, development of a prosthetic graft surface with sustained antimicrobial activity has always been an attractive strategy in order to prevent infection.