ABSTRACT
The synthesis of combinatorial libraries using solid-phase chemistry has become a routine strategy in the practice of drug discovery (1-3). Traditionally, the syn theses of nonpeptide libraries were initially developed in solution, enabling reac tion conditions and intermediates to be characterized by using conventional ana lytical techniques, and the resulting synthetic route was then transferred to the solid support using an appropriate linker (4). However, differences in reaction rates and yields between solid and solution phase (5) and the need to shorten reaction optimization time has led to an adoption of strategies in which the chem istry is developed directly on the solid support. Although this approach depends upon effective monitoring of reactions carried out on resin, the requisite analytical techniques remain limited (6 - 8 ).
