ABSTRACT
The analysis of parallel libraries produced by solid-phase or solution-phase chem istries is a relatively straightforward problem. Typically, milligram quantities of spatially separated discrete compounds are synthesized, optionally purified by high throughput parallel high performance liquid chromatography (HPLC) and characterized by a variety of classical analytical methods including HPLC, ultra violet spectrometry (UV), evaporative light scattering detection (ELSD), mass spectrometry (MS), and nuclear magnetic resonance (NMR). The ongoing con cern in parallel library compound analysis is the speed (throughput) at which this can be accomplished and associated informatics. It is also highly desirable to have a robust method of direct compound quantitation that does not require the use of an authentic standard. A number of commercial enterprises are working diligently to solve these issues.
