ABSTRACT
This chapter concerns the drugs that modulate the action of two types of hormone: insulin and analogues of gonadotrophin hormone releasing hormone (GnRH). Although we do not know the exact mechanism for the drugs that lower blood glucose or the detailed mechanism of action of insulin itself (e.g. the nature of the second messenger, if any), it is necessary to include the important area of anti-diabetic drugs. It is interesting to compare our limited knowledge of the mode of action of insulin, which has been investigated for several decades, with the way in which GnRH analogues, that have only been known for just over a decade, have broadened our knowledge of the relationship between hypothalamus, pituitary and gonads.
