ABSTRACT
Juan Sastre, Federico V. Pallardo, Jose Garcia de la Asuncion, Miguel A. Asensi, Juan M. Esteve, and Jose Vina-Ribes University of Valencia, Valencia, Spain
I. THE MITOCHONDRIAL THEORY OF AGING
One of the most relevant theories raised to explain aging is the free radical theory of aging, which was first proposed by Harman more than 40 years ago (1). Ac cording to this theory, oxygen-derived free radicals are responsible for ageassociated impairment at the cellular and tissue levels (1).
