ABSTRACT

C. Skin-Water Distribution System A characteristic feature of wet skin is that it is significantly more hydrogen-bond basic than water, whereas for the majority of stationary phases used in reversed-phase chromatography, the opposite appears to be true. Notable exceptions are the cationic surfactants hexadecyltrimethylammonium bromide [68] and dodecyltrimethylammonium bromide [71] used in micellar electrokinetic chromatography and the alkylamide-bonded phase, Supelcosil C-18 ABz+, with 40% (v/v) aqueous methanol as mobile phase in column liquid chromatography [25] (Table 16). The solvation parameter model for the skin-water distribution system was constructed from a limited range of solute types, steroids and alcohols, for which retention data are unavailable for the chromatographic systems. Consequently, we are unable to further test the usefulness of the correlation models identified in Table 16.