ABSTRACT

IARC MONOGRAPH 7 1974 AMITROLE INDUCED THYROID AND LIVER TUMORS IN BOTH MICE AND RATS FOLLOWING ORAL AND/OR SUBCUTANEOUS ADMINISTRATION. A SINGLE, SMALL COHORT STUDY RAISES THE SUSPICION THAT AMITROLE MAY BE CARCINOGENIC TO MAN, BUT THE FINDINGS CANNOT BE REGARDED AS CONCLUSIVE. IN A 1979 SUPPLEMENT, IARC DETERMINED THAT THERE IS SUFFICIENT EVIDENCE FOR THE CARCINOGENICITY OF AMITROLE IN ANIMALS.

IARC VOL 41 1986 SUFFICIENT EVIDENCE FOR CARCINOGENICITY OF CPD TO TEST ANIMALS BUT INADEQUATE EVIDENCE FOR CARCINOGENICITY TO HUMANS. LIMITED EVIDENCE FOR GENETIC ACTIVITY IN SHORT-TERM TESTS. ORAL ADMINISTRATION OF CPD TO MICE AND RATS INDUCED THYROID AND LIVER TUMORS. NO SKIN TUMORS SEEN AFTER TOPICAL APPLICATION ON MICE. NO CARCINOGENIC EFFECT SEEN IN HAMSTERS. A STATISTICALLY SIGNIFICANT EXCESS OF ALL TUMORS SEEN IN SUBCOHORT EXPOSED TO BOTH AMITROLE AND CHLOROPHENOXY HERBICIDES BUT NOT IN SUBCOHORT EXPOSED TO AMITROLE BUT NOT TO 2,4-D OR 2,4,5-T.