ABSTRACT
IARC VOL 41 1986 LIMITED EVIDENCE FOR CARCINOGENICITY OF CPD TO TEST ANIMALS, BUT NO EVALUATION COULD BE MADE OF ITS CARCINOGENICITY TO HUMANS. DEGREE OF EVIDENCE IN SHORT-TERM TESTS FOR GENETIC ACTIVITY IS INADEQUATE. NO DATA AVAILABLE TO EVALUATE REPRODUCTIVE EFFECTS OR PRENATAL TOXICITY OF CPD TO HUMANS. CHEMICAL INTERMEDIATE
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NTP TR 317 NIH PUB 86-2573 DEC 85 NO EVIDENCE OF CARCINOGENICITY IN F344/N RATS OR B6C3Fl MICE OF EITHER SEX ADMINISTERED CHLORPHENIRAMINE MALEATE IN DISTILLED WATER BY GAVAGE, 5 DAYS PER WEEK FOR 2 YEARS. DUE TO HIGH MORTALITY RATES IN HIGH DOSE FEMALE RATS AND HIGH DOSE MALE MICE, SENSITIVITY OF THESE GROUPS TO DETECT CARCINOGENIC RESPONSE WAS REDUCED. CHLORPHENIRAMINE MALEATE HAD PROLIFERATIVE EFFECT ON THYROID GLAND OF FEMALE MICE, AS SHOWN BY INCREASED INCIDENCES OF FOLLICULAR CELL CYSTS AND HYPERPLASIA IN BOTH LOW DOSE AND HIGH DOSE GROUPS. ANTIHISTAMINE DRUG
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NCI CARC TRS 45 DHEW PUB NO 78-845 IT IS CONCLUDED THAT UNDER THE CONDITIONS OF THIS BIOASSAY, CHLORPROPAMIDE WAS NOT CARCINOGENIC FOR FISCHER 344 RATS OR B6C3Fl MICE IN A FEEDING STUDY.
