ABSTRACT
NCI BIOASSAY PROGRAM, CANCER VOL. 40 1977 UNDER THE CONDITIONS OF THE BIOASSAY, IP INJECTION OF DACARBAZINE WAS CARCINOGENIC TO SWISS-WEBSTER MALE AND FEMALE MICE, CAUSING LUNG TUMORS, LYMPHOMAS, AND HEMANGIOMAS IN MALE MICE, AND LUNG AND UTERINE TUMORS IN FEMALE MICE. IT WAS ALSO CARCINOGENIC TO MALE AND FEMALE SPRAGUE-DAWLEY (CD) RATS, CAUSING LYMPHOMAS AND HEART TUMORS. IN ADDITION, MALE RATS HAD RENAL TUMORS AND FEMALE RATS HAD BREAST CARCINOMAS.
