ABSTRACT
NTPTECHNICAL BULLETIN 6 JAN 82 THE COMPOUND WAS POSITIVE IN THE S, TYPHIMURIUM MUTAGENICITY ASSAY IN ONE LABORATORY, ANTIOXIDANT FOR POL YOLEFIN PLASTICS AND FOOD ADDITIVE
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NCI CARC TRS 160 DHEW PUB NO 79-1716 UNDER THE CONDITIONS OF THIS BIOASSAY, 2,4,5-TRIMETHYLANILINE WAS CARCINOGENIC FOR MALE AND FEMALE F344 RATS AND FEMALE B6C3Fl MICE, INDUCING HEPATOCELLULAR CARCINOMAS OR NEOPLASTIC NODULES IN THE RATS OF EACH SEX, ALVEOLAR/BRONCHIOLAR CARCINOMAS IN THE FEMALE RATS, AND HEPATOCELLULAR CARCINOMAS IN THE FEMALE MICE (FEEDING STUDY),
NTP TECHNICAL BULLETIN 5/8 AUG 81, JUL 82 2,4,5-TMA WAS POSITIVE IN THE SALMONELLA ASSAY, BUT NEGATIVE IN DROSOPHILA WHEN TESTED FOR SEX-LINKED RECESSIVE LETHALS,
IARC MONOGRAPH 27 1982 2,4,5-TRIMETHYLANILINE AND ITS HCL WERE TESTED IN TWO EXPERIMENTS IN MICE AND TWO EXPERIMENTS IN RATS BY DIETARY ADMINISTRATION, ONE EXPERIMENT IN MICE WAS INADEQUATE FOR EVALUATION, IN THE OTHER, 2,4,5-TMA PRODUCED HEPATOCELLULAR CARCINOMAS IN FEMALE MICE, IN ONE STUDY IN RATS THERE WAS NO SIGNIFICANT INCREASE IN TUMORS, IN THE OTHER, IT PRODUCED LIVER CARCINOMAS AND LUNG ADENOMAS, THERE IS LIMITED EVIDENCE FOR THE CARCINOGENICITY OF 2,4,5-TMA IN ANIMALS,
IARC MONOGRAPH 27 1982 2,4,5-TRIMETHYLANILINE WAS MUTAGENIC TO SALMONELLA WITH METABOLIC ACTIVATION, NO DATA CONCERNING EFFECTS ON REPRODUCTION OR PRENATAL TOXICITY WERE AVAILABLE, DYE INTERMEDIATE FOR FOOD COLOR; NO KNOWN CURRENT PRODUCTION
REPORT 01 IARC MONOGRAPH 27 1982 2,4,6-TRIMETHYLANILINE WAS TESTED IN ONE EXPERIMENT IN
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WERE CONSIDERED INADEQUATE FOR EVALUATION.
