ABSTRACT
NCI BIOASSAY PROGRAM, CANCER VOL. 40 1977 UNDER THE CONDITIONS OF THE BIOASSAY, I.P. INJECTION OF VINCRISTINE WAS NOT CARCINOGENIC TO SWISS-WEBSTER MICE OR SPRAGUE-DAWLEY (CD) RATS OF EITHER SEX.
IARC MONOGRAPH 26 1981 VINCRISTINE SULPHATE CAN INDUCE TERATOGENIC EFFECTS IN SEVERAL ANIMAL SPECIES, AND IT INDUCED EMBRYOLETHALITY AT DOSES NONTOXIC TO THE MOTHER. THERE IS NO EVIDENCE TO SUGGEST THAT THIS COMPOUND IS MUTAGENIC.
