ABSTRACT
The choice of a specific microorganism for use in a fermentation process has a direct influence on the design of the bioreactor. The impact that the microorganism has on the overall process is multifaceted, in part due to its complexity as a living entity and the ensuing complexity of conditions inside the bioreactor. Consequently, no general models for fermentation scale-up exist which can readily take into account the enormous diversity of the biology of the relevant organisms. As a result, scale-up is dependent on experimental results from small and pilot plant studies.
