ABSTRACT
Cellular level s o f 2 , 3 - D P G ca n var y dependin g o n th e functionin g o f th e
glycolytic pathway . Thi s i s especiall y obviou s i n glycolyti c enzym e deficiencies .
For instance , i n hexokinase deficiency , w h e n cellula r triose phosphat e level s ar e
low, a decreas e i n 2 , 3 - D P G productio n i s observed . Thi s cause s th e stabilizatio n
of oxyhemoglobi n i n the R form, impeding 0 2 releas e int o th e periphera l tissues.
