ABSTRACT
Biodegradable poly(butyl cyanoacrylate) (PBCA) nanoparticles, when overcoated with the nonionic surfactant polysorbate, could signicantly enhance the enrichment of loaded doxorubicin (DOX) in the brain compared to the uncoated nanoparticles, after intravenous administration to rats (Gulyaev et al. 1999). When glioblastoma-bearing rats were subjected to the DOX-bound polysorbate-coated nanoparticles, a signicant increase in rat survival time was observed compared to other control groups, with more than 20% of the animals in the former group showing a long-term remission (Steiniger et al. 2004). Surface functionalization of PBCA nanoparticles with other surfactants, such as poloxamer 188 (Pluronic F68), could also enhance the antitumor effect of DOX against intracranial glioblastoma (Ambruosi et al. 2006).
