ABSTRACT
Carbon dioxide (CO2) has drawn much attention from the viewpoint of global warming as well as one of the most promising alternatives to phosgene.1 The chemical conversion of CO2 is a viable approach to utilize an abundant and inexpensive C1 feedstock.1,2 The preparation of oxazolidinones is one of the most attractive synthetic methods from CO2. Much effort has been made to develop the chemical xation of CO2 into propargylic amines to provide the oxazolidinone derivatives (Scheme 3.1) because of oxazolidinones showing a wide application as intermediates3 and chiral auxiliaries4 in organic synthesis. A green effective catalytic process
Introduction .............................................................................................................. 47 Reaction Procedures ................................................................................................. 49
Synthesis of N-Benzylprop-2-yn-1-Amine from Propargyl Bromide ................ 49 The Procedure for the Cyclization Reactions of N-Benzylprop-2-yn-1Amine with CO2 ..................................................................................................50
Notes ........................................................................................................................50 Instrumentation ...................................................................................................50 Safety Warning .................................................................................................... 52
Importance on Green Chemistry Context ................................................................ 52 Evaluation from the Viewpoint of the 12 Principles ................................................ 53 References ................................................................................................................54
(Figures 3.1 to 3.3 and Table 3.1) for CO2 xation of the propargyl amine to the oxazolidinone catalyzed by ion-exchange resin D301R under mild reaction conditions was developed (Scheme 3.2).5
